GHK Cu vs NAD+: Which Longevity Peptide Should You Take or Stack? Exercise training augments Sirt1 signaling and attenuates cardiac inflammation in D galactose induced aging rats Aging How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin AMPK Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation: Molecular Cell