ME CFS (Myalgic Encephalomyelitis Chronic Fatigue Syndrome) is a complex condition that can occur after an infection (like the flu, mono, COVID 19, etc.). For some, there's no clear trigger, but regardless, the illness is Frontiers Myalgic Encephalomyelitis Chronic Fatigue Syndrome: the biology of a neglected disease A Perspective on the Role of Metformin in Treating Myalgic Encephalomyelitis Chronic Fatigue Syndrome (ME CFS) and Long COVID ACS Pharmacology & Translational Science Polyphenols as possible alternative agents in chronic fatigue: a review Phytochemistry Reviews Springer Nature Link
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