Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy Targeting gut microbiota to counteract acetaminophen induced acute liver injury: Trends in Microbiology Tylenol And Glutathione Invigor Medical Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.