Is Tylenol Bad? 5 Dangers for Children & Adults Done With Diligence Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Avoid Tylenol with vaccines. A key reminder often emphasized in vaccine education is to avoid using Tylenol (acetaminophen) alongside vaccination. Tylenol requires glutathione for proper metabolism in the body. When glutathione Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.