Headaches suck. There are many reasons why one gets headaches. Some reasons: Low serotonin, high histamine, low glutathione, low folate, high oxidative stress, high aldehydes, low biopterin Dehydration is a major cause What are the Side Effects of Glutathione? Treating Migraine With Infusions National Headache Foundation Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic