MTHFR Gene Explained: C677T and A1298C Variants, Testing, and Solutions Common MTHFR Mutations and General Health Are Your Genes Sabotaging Your Health? Understanding the Impact of MTHFR Mutation": Weight Loss and Vitality: Medical Weight Loss The MTHFR gene mutation is the world's biggest translation problem. If you're born with it, your body can't understand the language of standard vitamins. Even if you ingest them, they'll pass through,