Coffee Enemas at Home: Benefits, Risks & What You Must Know Before You Try Them Euphoria Medspa Ozonating coffee enemas combines two powerful therapies. The coffee stimulates hepatic glutathione S transferase, upregulating detoxification pathways in the liver. It also increases glutathione Trust Your Gut Enema Coffee Bethany's Pantry Coffee enemas probably won't detox your system they're more likely to cause you serious damage