Blister Cell in G6PD Deficiency , Red Blood Cell with a clear vacuole like area on its membrane, resembling a blister., It usually results when splenic macrophages remove precipitated Heinz Glucose 6 Phosphate Dehydrogenase an overview ScienceDirect Topics In G6PD deficiency (XR), we have increased oxidative damage to RBCs, leading to intravascular hemolysis with decreased serum haptoglobin. We have decreased NADPH production, which means decreased conversion of oxidized ( S S ) glutathione Although G6PD deficiency, which can cause problems in red blood cells upon certain triggers, is the most common human enzyme defect, affecting over 400 million people, including over 1 in 10 Black