Genital melanotic macules: Clinical, histologic, immunohistochemical, and ultrastructural features ScienceDirect Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Melanocytic Lesions of the Vulva Obgyn Key Melanotic macule of nail unit and its clinicopathologic spectrum
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