Unraveling the Formation Mechanisms of Trimethylamine N Oxide and Its Inhibition by Food Ingredients: Toward Cardioprotective Food Development Journal of Agricultural and Food Chemistry Trimethylamine N oxide (TMAO) is a small molecule produced in humans primarily by the gut liver axis and has become an important biomarker, and possible mediator, of cardiometabolic and renal disease. Dietary choline, phosphatidylcholine ( Cardiovascular risk of dietary trimethylamine oxide precursors and the therapeutic potential of resveratrol and its derivatives Hou 2024 FEBS Open Bio Wiley Online Library The anti atherogenic bioactive metabolites of natural medicine generated by host microbe co metabolism system. The terminal metabolites of low bioavailable polysaccharides are SCFAs, among which propionate and butyrate can effectively attenuate
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